RE: Upcoming Bo Nickal fight in UFC 300: I have never seen Vegas odds like this before

Betting on underdogs can be a lot of fun and yes, you don't have to win many of them to really come out on top. Extreme underdogs like this are very rare though. Most of the time the fights are +/- 200 or so, so the incentive to bet always on the underdog isn't really there. The house always wins!