Throughout its history, Dortmund has visited Spanish territory on many occasions, having faced seven different teams in various competitions, to face 15 external confrontations.
The match comes amid uncertainty about the performance and results of the German team recently, which portends the imminent overthrow of Swiss coach Lucien Favre.
Borussia Dortmund face a tough encounter away to Barcelona at the Camp Nou on Wednesday in the fifth round of the Champions League group stage.
The Festivals are second in Group F with seven points, one point behind leaders Barcelona, after Favre's men won two games, lost one and tied it.
During the clashes, Dortmund missed victories, with the exception of a one-off clash at Atletico Madrid in the Champions League group stage during the 1996-97 season, when they won 1-0.
The Real, the most welcoming team of the Black Festival, after hosting him in seven encounters, during which the German team did not succeed in any victory, as they lost on five occasions, and drew twice.
In general, Dortmund suffered a loss in nine encounters, and a draw in the other five, only to beat the orphans Atleti, making his visit to Camp Nou risky.
Dortmund had never met Barça in their stronghold only in the 1997-1998 season, when they were in the first leg of the European Super Cup, ending in a 2-0 victory for the Catalans.